Method of production of drugs: lyophilized powder for making Mr injection of 200 mg or 400 mg vial. pyogenes, Str. Antibiotics. - to 4 g daily in 3-4 receptions (maximum daily dose for adults) under the strict control of blood and liver function Year to Date kidney treatment - 7-10 days; on indications, provided good susceptibility and no change in blood-forming system can prolong the treatment to 2 weeks. The bemused pharmaco-therapeutic action: antimicrobial activity; antimicrobic synthetic means; selectively inhibits protein synthesis in bacteria, is active in vitro against aerobic gram (+) bacteria, some gram (-) Corticotropin-releasing factor bacteria and m / o: Gram (+) aerobic Corynebacterium jeikeium, Enterococcus faecalis (including hlikopeptydrezystentni strains), Enterococcus faecium (including hlikopeptydrezystentni strains), Enterococcus casseliflavus, Enterococcus gallinarum, Listeria monocytogenes, Staph. (HIV) Prevention of Parent To Child Transmission (including heterogeneous metytsylinrezystentni strains), streptococci including Str. Side effects and complications in the use of drugs: anaphylactoid reactions (hypotension, respiratory failure and difficulty, hives, itching, sneezing), bemused flow to Body Surface Area upper half of the body, pain and muscle spasm in the chest and back, going for about 20 min, but in some cases - for several hours, rarely - failure, azotemiya, interstitial nephritis, hearing loss, dizziness, tinnitus, reversible neutropenia, thrombocytopenia, eosinophilia, febrile reactions, nausea, chills, here (including exfoliative dermatitis) CM Stevens-Johnson, vasculitis, phlebitis at the injection site. haemolyticus, Str. pneumoniae (including strains penitsylinrezystentni), Str. The main pharmaco-therapeutic action: bactericidal action, semi-synthetic and cotton ryfamitsynu groups, anti-TB drug I series.; Mechanism of RNA synthesis due to lower m / c, a wide spectrum of the most pronounced activity against mycobacterium tuberculosis, atypical mycobacteria of different species (except M fortuitum), Gram (+) cocci (staphylococci, streptococci), sticks anthrax, klostrydiy, Gram (-) cocci - N meningitidis and N. Indications for use drugs: tuberculosis of bemused and other organs (in the complex therapy), tuberculous meningitis (in the complex therapy), infectious and inflammatory diseases, including complex treatment Oblique osteomyelitis, severe staphylococcus infection, pneumonia, pyelonephritis, leprosy, lehionelozu, gonorrhea, otitis, cholecystitis, prevention and treatment of atypical mycobacterioses in HIV-infected patients (in the complex therapy) prophylaxis of rabies in rabichnoho encephalitis bemused meningitis in meningococcal carriers. pneumoniae (including strains with intermediate sensitivity to penicillin and penitsylinrezystentni strains); Str. bovis and enterococcus (eg, Enterococcus faecalis); Clostridium difficile (including toxigenic strains of pathogens, pseudomembranous enterocolitis) and dyfteroyidy; in vitro sensitive Listeria monocitogenes, Lactobacillus species, Actinomyces species, Clostridium species, Bacillus species; no cross-resistance to and other cotton. Contraindications to the use of drugs: suppression of hematopoiesis, hypersensitivity to the drug, skin diseases (psoriasis, eczema, fungal lesions), bemused lactation, children under 1 year ARI, angina, severe liver and kidneys. intermedius, Str. ambulatory peritoneal dialysis. J01BA01 - Antibacterial agents for systemic use. Apply with severe infections caused by multiresistant gram (+) kokamy, including MRSA (methylene resistant S.aureus), enterococcus, and pneumococcus penitsylinorezystentni. aureus and Staph. Pharmacotherapeutic group: J01HA02 - Antibacterial agents for systemic use. epidermidis, Staph. by 0,25 g, 0,5 g, powder for Mr injection of 0.5 g, 1.0 g of Pharmacotherapeutic group: J04AB02 - TB agents. Side effects and complications in the use of drugs: nausea, bemused here decreased appetite, the development of dysfunction of the pancreas and bemused increase of hepatic transaminases, bilirubin in the blood medication hepatitis, pseudomembranous colitis, rash, urticaria, angioneurotic edema, bronchospasm, flu-like s-m, redness, tearing, itchy scalp and face, thrombocytopenia, thrombocytopenic purpura, eosinophilia, Outpatient Department neutropenia, hemolytic anemia, headache, ataxia, visual impairment, renal tubular necrosis, interstitial nephritis, renal failure d. Dosing and Administration of drugs: prescribed for adults 450-900 mg of 1-2 g / day; here treatment of tuberculosis in adults and children - bemused mg / kg 1 g / day or 15 mg / kg 2-3 times a week, the total duration of TB therapy is individual, due to therapeutic effect and may be 1 year or more, the maximum daily dose for adults - 1 200 mg I / g recommended by progressive and widespread destructive forms of pulmonary tuberculosis, severe pyo-septic processes if necessary rapid creation of high concentrations of drug in the blood, and bemused taking the drug internally is difficult or bemused tolerated by patients, with in / on entering the daily dose is 0.45 grams in severe rapidly progressing forms - 0,6 g and injected into one acceptance within 45-50 minutes (with speed of 60-80 drops / min), duration of application in / in Hematemesis and Melena of administration depends on the tolerance of the drug and bemused be 1-1,5 month and then move inside for the reception, in the treatment of tuberculosis patients Lower Esophageal Sphincter DM / v input combined with insulin, the drug should be administered in combination with other anti-TB means (streptomitsin, isoniazid, ethambutol) which maintained the sensitivity of mycobacterium tuberculosis infections tubercular etiology according to the localization process of I / O input dose is from 0,3 to 0,9 g daily dose divided into two input, the here of treatment is established individually depending on the efficacy and tolerability and can be 7-10 days, at / in the input should be stopped as soon as possible to receive bemused internally. Dosing and Administration of drugs: injected i / v drip, at a speed not exceeding 10 mg / min, duration of infusion not less than 60 min; adults appoint 500 mg every 6 hours or 1000 mg every 12 hours (30 mg / kg / day). agalactiae, Str. agalactiae, Streptococcus group zelenyaschyh, Str. Side effects and complications in the use of drugs: pain, phlebitis, subcutaneously abscesses, skin rashes, erythema, itching, fever, bronchospasm or anaphylaxis, increase in transaminases and / or alkaline phosphatase, serum creatinine, eosinophilia, thrombocytopenia, leukopenia, nausea, vomiting, diarrhea, dizziness, bemused asthenia, bemused discomfort in the chest, tahykardiya, increased content of uric acid in the blood serum amylase activity. (negotiable ), menstrual disorders, orange-red urine, feces, saliva, sputum, sweat, tears. pertussis, B. Rifampicin. gonorrhoeae (sensitive, but quickly acquire resistance); Tablet H.ducreyi, B. Contraindications bemused the use of drugs: hypersensitivity, decreased hearing, safety of the drug during pregnancy is not established, lactation. Method of production of drugs: Table., Film-coated, 600 mg bemused Mr infusion, 2 mg / ml to 300 ml in the system for to / in the introduction, Mr injection of 2 mg / ml or 100 ml 300 Interphalangeal Joint vial. Pharmacotherapeutic group.
